Sertraline Racemate and Enantiomer: Solid-State Characterization, Binary Phase Diagram, and Crystal Structures

被引：11

作者：

He, Quan ^{[1
]}

Rohani, Sohrab ^{[1
]}

Zhu, Jesse ^{[1
]}

Gomaa, Hassan ^{[1
]}

机构：

[1] Univ Western Ontario London, Dept Chem & Biochem Engn, London, ON N6G 4R3, Canada

来源：

CRYSTAL GROWTH & DESIGN | 2010年 / 10卷 / 04期

关键词：

ACTIVE PHARMACEUTICAL INGREDIENTS; SALT SELECTION; CRYSTALLIZATION; POLYMORPHISM;

D O I：

10.1021/cg901197b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The racemate and enantiomer of sertraline free base were prepared and characterized. The crystalline sertraline enantiomer is relatively less polymorphic corn pared with the sertraline-HC1 salt. The solid-state nature of sertraline racemate was identified to be a racemic compound thruigh a binary melting point phase diagram and spectroscopy analysis. The crystal structures of the racemate and enantiomer were determined to be monoclinic P12(1)/n(1) and P2(1), respectively.

引用

页码：1633 / 1645

页数：13

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