Basic fibroblast growth factor promotes bone marrow stromal cell transplantation-mediated neural regeneration in traumatic brain injury

被引：66

作者：

Bhang, Suk Ho

Lee, Young Eun

Cho, Seung-Woo

Shim, Jae-Won

Lee, Sang-Hun

Choi, Cha Yong

Chang, Jin Woo ^{[1
]}

Kim, Byung-Soo

机构：

[1] Hanyang Univ, Dept Bioengn, Seoul 133791, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151742, South Korea

[3] Yonsei Univ, Coll Med, Brain Korea Project Med Sci 21, Seoul 120752, South Korea

[4] Yonsei Univ, Coll Med, Dept Neurosurg, Seoul 120752, South Korea

[5] Hanyang Univ, Coll Med, Dept Biochem & Mol Biol, Seoul 133791, South Korea

[6] Hanyang Univ, Inst Mental Hlth, Seoul 133791, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2007年 / 359卷 / 01期

关键词：

basic fibroblast growth factors; bone marrow stromal cell; brain trauma injury; fibrin gel;

D O I：

10.1016/j.bbrc.2007.05.046

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current study was designed to evaluate the effects of basic fibroblast growth factor (bFGF) on human BMSC (hBMSC) transplantation-mediated neural regeneration in traumatic brain injury (TBI). Fibrin gel was used as a delivery vehicle to release bFGF locally in the TBI sites in a controlled manner. To test this hypothesis, hBMSCs suspended in fibrin gel containing bFGF were transplanted to rat TBI sites. Transplantation of hBMSCs suspended in fibrin gel without bFGF served as a control. hBMSC transplantation and bFGF treatment showed enhanced neural tissue regeneration than that of the control. The infarction volume and apoptotic activity of the transplanted hBMSCs were significantly decreased, and functional outcomes were significantly improved in the hBMSC transplantation and bFGF treatment group than in the control group. This study demonstrates that bFGF significantly enhances histological and functional recovery when used in hBMSC transplantation therapy in TBI. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：40 / 45

页数：6

共 31 条

[1] Evidence for integrity of the growth hormone/insulin-like growth factor-1 axis in patients with severe head trauma during rehabilitation [J].