What does it take to make a natural killer?

被引：367

作者：

Colucci, F

Caligiuri, MA

Di Santo, JP

机构：

[1] Inst Pasteur, Dept Immunol, Cytokines & Lymphoid Dev Unit, F-75724 Paris, France

[2] Ohio State Univ, James Canc Hosp & Comprehens Canc Ctr, Dept Internal Med, Div Haematol & Oncol, Columbus, OH 43210 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 05期

关键词：

D O I：

10.1038/nri1088

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We know how B and T cells develop, what they 'see' and the receptors they 'see with'. By contrast, and despite an unprecedented increase in the number of receptors and ligands known to regulate the activity of natural killer (NK) cells, we still have many questions regarding how these cells develop. Nevertheless, we are beginning to understand the transcriptional programmes of NK-cell maturation and the role of the effector functions of NK cells in the regulation of immune responses. An improved knowledge of NK-cell development in mice and humans might be useful to harness the power of these natural killers in the clinic to fight autoimmune diseases, infection and cancer.

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页码：413 / 425

页数：13

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