Accelerated atherosclerosis in inflammatory rheumatic diseases

被引：40

作者：

Haskard, DO ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Eric Bywaters Ctr Vasc Inflammat, London W12 0NN, England

来源：

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 2004年 / 33卷 / 05期

关键词：

D O I：

10.1080/03009740410010281

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Over recent years it has become clear that patients with inflammatory rheumatic diseases are at increased risk of developing atherosclerosis. The exact causes for this are probably related in part to a general adverse effect of inflammation on atherogenesis, and in part to immune mechanisms specific to individual rheumatic diseases. This review discusses proposed mechanisms of accelerated atherosclerosis, including abnormal lipid and lipoprotein profiles, oxidative stress, enhanced apoptosis, thrombophilia, immune complexes, and increased mononuclear cell infiltration of atherosclerotic lesions, and local generation of cytokines.

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页码：281 / 292

页数：12

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