Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa

被引：148

作者：

Kohler, T ^{[1
]}

MicheaHamzehpour, M ^{[1
]}

Plesiat, P ^{[1
]}

Kahr, AL ^{[1
]}

Pechere, JC ^{[1
]}

机构：

[1] HOP JEAN MINJOZ,BACTERIOL LAB,F-25000 BESANCON,FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 11期

关键词：

D O I：

10.1128/AAC.41.11.2540

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF-OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.

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页码：2540 / 2543

页数：4

相关论文

共 21 条

[1]

BRYSON V, 1952, SCIENCE, V116, P45, DOI 10.1126/science.116.3003.45

[2] NEW NORFLOXACIN RESISTANCE GENE IN PSEUDOMONAS-AERUGINOSA PAO [J].

FUKUDA, H ;

HOSAKA, M ;

HIRAI, K ;

IYOBE, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (09) :1757-1761

[3] NFXC-TYPE QUINOLONE RESISTANCE IN A CLINICAL ISOLATE OF PSEUDOMONAS-AERUGINOSA [J].

FUKUDA, H ;

HOSAKA, M ;

IYOBE, S ;

GOTOH, N ;

NISHINO, T ;

HIRAI, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (03) :790-792

[4] MUTATIONS PRODUCING RESISTANCE TO NORFLOXACIN IN PSEUDOMONAS-AERUGINOSA [J].

HIRAI, K ;

SUZUE, S ;

IRIKURA, T ;

IYOBE, S ;

MITSUHASHI, S .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1987, 31 (04) :582-586

[5] OCCURRENCE OF THE NFXB TYPE MUTATION IN CLINICAL ISOLATES OF PSEUDOMONAS-AERUGINOSA [J].

JAKICS, EB ;

IYOBE, S ;

HIRAI, K ;

FUKUDA, H ;

HASHIMOTO, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (11) :2562-2565

[6]

JORGENSEN JH, 1997, METHODS DILUTION ANT

[7] Multidrug efflux in intrinsic resistance to trimethoprim and sulfamethoxazole in Pseudomonas aeruginosa [J].

Kohler, T ;

Kok, M ;

MicheaHamzehpour, M ;

Plesiat, P ;

Gotoh, N ;

Nishino, T ;

Curty, LK ;

Pechere, JC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (10) :2288-2290

[8] Characterization of MexE-MexF-OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa [J].

Kohler, T ;

MicheaHamzehpour, M ;

Henze, U ;

Gotoh, N ;

Curty, LK ;

Pechere, JC .

MOLECULAR MICROBIOLOGY, 1997, 23 (02) :345-354

[9] OUTER-MEMBRANE ALTERATIONS IN MULTIRESISTANT MUTANTS OF PSEUDOMONAS-AERUGINOSA SELECTED BY CIPROFLOXACIN [J].

LEGAKIS, NJ ;

TZOUVELEKIS, LS ;

MAKRIS, A ;

KOTSIFAKI, H .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (01) :124-127

[10] ROLE OF MEXA-MEXB-OPRM IN ANTIBIOTIC EFFLUX IN PSEUDOMONAS-AERUGINOSA [J].

LI, XZ ;

NIKAIDO, H ;

POOLE, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1995, 39 (09) :1948-1953