FLT3/internal tandem duplication subclones in acute myeloid leukemia differ in their engraftment potential in NOD/SCID mice

被引：10

作者：

Cheung, Alice M. S. ^{[1
]}

Chow, Howard C. H. ^{[1
]}

Kwong, Yok-Lam ^{[1
]}

Liang, Raymond ^{[1
]}

Leung, Anskar Y. H. ^{[1
]}

机构：

[1] Univ Hong Kong, Div Hematol, Dept Med, Hong Kong, Hong Kong, Peoples R China

来源：

LEUKEMIA RESEARCH | 2010年 / 34卷 / 01期

关键词：

FLT3/internal tandem duplication; NOD/SCID mice; AML; Leukemia stem cells; BONE-MARROW; FLT3;

D O I：

10.1016/j.leukres.2009.07.035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this study, we tested if FLT3/internal tandem duplication (ITD) in acute myeloid leukemia (AML) might occur at different hierarchical stages during leukemogenesis. In 56 AML cases, 10 showed FLT3/ITD (single ITD = 5; multiple ITD = 5). Myeloblasts from seven cases (CD34-selected = 4; unselected = 3) were transplanted into NOD/SCID mice. Five cases engrafted successfully into 14 mice. Two patients carried single FLT3/ITD subclones, which were maintained during primary and secondary transplantations. In three patients with multiple FLT3/ITD subclones, some subclones persisted or expanded while others diminished upon transplantation. Their different engraftment capabilities in NOD/SCID mice supported the proposition that FLT3/ITD might occur at different stages during leukemogenesis. (c) 2009 Elsevier Ltd. All rights reserved.

引用

页码：119 / 122

页数：4

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