学术探索
学术期刊
新闻热点
数据分析
智能评审

Chemistry and clinical biology of the bryostatins

被引：156
作者：
Mutter, R [1 ]
Wills, M [1 ]
机构：
[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2000年 / 8卷 / 08期
关键词：
D O I：
10.1016/S0968-0896(00)00150-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bryostatins are a class of antineoplastic compounds isolated from the bryozoans Bugula neritina. A wide range of scientific research is currently underway, studying different aspects of the bryostatins. In this review we try to summarize the latest findings, including all the topics involved, from marine biology to medicinal chemistry. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1841 / 1860
页数：20
相关论文
共 101 条
  • [1] Al-Katib AM, 1998, CLIN CANCER RES, V4, P1305
  • [2] Modulation of the expression of Bcl-2 and related proteins in human leukemia cells by protein kinase C activators: Relationship to effects on 1-[beta-D-arabinofuranosyl]cytosine-induced apoptosis
    Bartimole, TM
    Vrana, JA
    Freemerman, AJ
    Jarvis, WD
    Reed, JC
    Boise, LH
    Grant, S
    [J]. CELL DEATH AND DIFFERENTIATION, 1997, 4 (04) : 294 - 303
  • [3] Regulation of caspase activation and cis-diamminedichloroplatinum(II)-induced cell death by protein kinase C
    Basu, A
    Akkaraju, GR
    [J]. BIOCHEMISTRY, 1999, 38 (14) : 4245 - 4251
  • [4] Beck FWJ, 1998, BLOOD, V92, p191B
  • [5] Results of a randomized phase II study of two schedules of bryostatin-I in patients with malignant melanoma: Experience with the multivariate stopping rule
    Belanger, K
    Tozer, R
    Burdette-Radoux, S
    Davis, M
    Lohmann, R
    Zee, B
    Wainman, N
    Seymour, L
    [J]. EUROPEAN JOURNAL OF CANCER, 1999, 35 : S374 - S374
  • [6] *BIOMOL RES LAB, PLYM M PA
  • [7] The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas
    Bodily, JM
    Hoopes, DJ
    Roeder, BL
    Gilbert, SG
    Pettit, GR
    Herald, CL
    Rollins, DN
    Robison, RA
    [J]. CANCER LETTERS, 1999, 136 (01) : 67 - 74
  • [8] Bögi K, 1998, CANCER RES, V58, P1423
  • [9] The antineoplastic agent bryostatin-1 induces proinflammatory cytokine production in human monocytes: Synergy with interleukin-2 and modulation of interleukin-2R gamma chain expression
    Bosco, MC
    Rottschafer, S
    Taylor, LS
    Ortaldo, JR
    Longo, DL
    EspinozaDelgado, I
    [J]. BLOOD, 1997, 89 (09) : 3402 - 3411
  • [10] Potentiation of ara-C-induced apoptosis by the protein kinase C activator bryostatin 1 in human leukemia cells (HL-60) involves a process dependent upon c-Myc
    Chelliah, J
    Freemerman, AJ
    WuPong, S
    Jarvis, WD
    Grant, S
    [J]. BIOCHEMICAL PHARMACOLOGY, 1997, 54 (05) : 563 - 573
12345678910