Copper-Catalyzed Guanidinylation of Aryl Iodides: The Formation of N,N′-Disubstituted Guanidines

被引：27

作者：

Cortes-Salva, Michelle ^{[1
]}

Nguyen, Be-Lan ^{[1
]}

Cuevas, Javier ^{[2
]}

Pennypacker, Keith R. ^{[2
]}

Antilla, Jon C. ^{[1
]}

机构：

[1] Univ S Florida, Dept Chem, Tampa, FL 33620 USA

[2] Univ S Florida, Coll Med, Dept Mol Pharmacol & Physiol, Tampa, FL 33612 USA

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 06期

关键词：

SELECTIVE LIGAND; AMINATION; ACID; HALIDES; POTENT; RECEPTORS; CHANNELS; DESIGN;

D O I：

10.1021/ol1002175

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N'-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/ligand system provided a simple diarylation procedure.

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收藏

页码：1316 / 1319

页数：4

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