NRG1 and synaptic function in the CNS

被引：24

作者：

Fischbach, Gerald D. ^{[1
]}

机构：

[1] Columbia Univ, New York, NY 10027 USA

[2] Simons Fdn Autism Res Initiat, New York, NY 10003 USA

来源：

NEURON | 2007年 / 54卷 / 04期

关键词：

D O I：

10.1016/j.neuron.2007.05.009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent genetic evidence indicates that neuregulin 1 (NRG1) and its receptor erbB4 may be susceptibility genes in schizophrenia, but their function in CNS synaptic transmission and circuitry is not well understood. In this issue of Neuron, studies from Li et al. and Woo et al. show that NRG1 and erbB4 regulate transmission at brain glutamate and GABA synapses. These findings raise the possibility of synaptic defects in schizophrenia.

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收藏

页码：495 / 497

页数：3

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