The role of immune responses in bone loss during periodontal disease

被引：114

作者：

Baker, PJ ^{[1
]}

机构：

[1] Bates Coll, Dept Biol, Lewiston, ME 04240 USA

来源：

MICROBES AND INFECTION | 2000年 / 2卷 / 10期

关键词：

periodontal disease; bone remodeling; interleukin-1; interleukin-6; tumor necrosis factor alpha; RANK-ligand;

D O I：

10.1016/S1286-4579(00)01272-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A network of cytokines and other soluble mediators unites the immune system and bone; bacterial infections induce immune responses which may perturb this network. Periodontal diseases are Gram-negative infections resulting in bone loss in the jaw. Evidence is presented that immune responses to these infections produces net resorption of bone. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

引用

页码：1181 / 1192

页数：12

共 91 条

[1] [Anonymous], 1996, Ann Periodontol, V1, P926
[2] Assuma R, 1998, J IMMUNOL, V160, P403
[3] CD4+ T cells and the proinflammatory cytokines gamma interferon and interleukin-6 contribute to alveolar bone loss in mice
Baker, PJ
Dixon, M
Evans, RT
Dufour, L
Johnson, E
Roopenian, DC
[J]. INFECTION AND IMMUNITY, 1999, 67 (06) : 2804 - 2809
[4] ORAL INFECTION WITH PORPHYROMONAS-GINGIVALIS AND INDUCED ALVEOLAR BONE LOSS IN IMMUNOCOMPETENT AND SEVERE COMBINED IMMUNODEFICIENT MICE
BAKER, PJ
EVANS, RT
ROOPENIAN, DC
[J]. ARCHIVES OF ORAL BIOLOGY, 1994, 39 (12) : 1035 - 1040
[5] Serum antibody response to oral infection precedes but does not prevent Porphyromonas gingivalis-induced alveolar bone loss in mice
Baker, PJ
Carter, S
Dixon, M
Evans, RT
Roopenian, DC
[J]. ORAL MICROBIOLOGY AND IMMUNOLOGY, 1999, 14 (03): : 194 - 196
[6] BAKER PJ, 2000, IN PRESS INFECT IMMU
[7] CHINESE-HAMSTER OVARIAN-CELLS TRANSFECTED WITH THE MURINE INTERLEUKIN-6 GENE CAUSE HYPERCALCEMIA AS WELL AS CACHEXIA, LEUKOCYTOSIS AND THROMBOCYTOSIS IN TUMOR-BEARING NUDE-MICE
BLACK, K
GARRETT, IR
MUNDY, GR
[J]. ENDOCRINOLOGY, 1991, 128 (05) : 2657 - 2659
[8] Taxonomy, biology, and periodontal aspects of Fusobacterium nucleatum
Bolstad, AI
Jensen, HB
Bakken, V
[J]. CLINICAL MICROBIOLOGY REVIEWS, 1996, 9 (01) : 55 - +
[9] Brown L J, 1993, Periodontol 2000, V2, P57
[10] Non-classical-MHC genetics of immunological disease in man and mouse. The key role of pro-inflammatory cytokine genes
Daser, A
Mitchison, H
Mitchison, A
Muller, B
[J]. CYTOKINE, 1996, 8 (08) : 593 - 597

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