Domain-ligand mapping for enzymes

被引：5

作者：

Bashton, Matthew ^{[1
]}

Thornton, Janet M. ^{[1
]}

机构：

[1] EMBL European Bioinformat Inst, Cambridge CB10 1SD, England

来源：

JOURNAL OF MOLECULAR RECOGNITION | 2010年 / 23卷 / 02期

关键词：

cognate ligand; protein domains; domain-ligand mapping; CATH; SCOP; Pfam; PROTEIN DATA-BANK; ACCESSIBLE DATABASE; BINDING; CLASSIFICATION; SITES; PDB; AFFINITIES; COMPLEXES; EVOLUTION;

D O I：

10.1002/jmr.992

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this paper we provide an overview of our current knowledge of the mapping between small molecule ligands and protein domains. We give an overview of the present data resources available on the Web, which provide information about protein-ligand interactions, as well as discussing our own PROCOGNATE database. We present an update of ligand binding in large protein superfamilies and identify those ligands most frequently utilized by nature. Finally we discuss potential uses for this type of data. Copyright (C) 2009 John Wiley & Sons, Ltd. Supporting information may be found in the online version of this paper.

引用

收藏

页码：194 / 208

页数：15

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