Intra-nuclear microtubules and a mitotic spindle orientation checkpoint

被引：30

作者：

Zimmerman, S ^{[1
]}

Daga, RR ^{[1
]}

Chang, F ^{[1
]}

机构：

[1] Columbia Univ Coll Phys & Surg, Dept Microbiol, New York, NY 10032 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/ncb1200

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cells of the fission yeast Schizosaccharomyces pombe have a checkpoint mechanism that reportedly monitors the orientation of the mitotic spindle. Astral microtubules in pre-anaphase spindles are thought to contact the contractile actin ring at the plasma membrane in order to rotate the spindle and to sense spindle orientation. Here, we show that these microtubules are actually inside the nuclear envelope.

引用

页码：1245 / 1246

页数：2

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