Gene conversion drives GC content evolution in mammalian histones

被引：123

作者：

Galtier, N ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, UMR 5000, F-34095 Montpellier, France

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 02期

关键词：

D O I：

10.1016/S0168-9525(02)00002-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To examine the evolutionary influence of gene conversion on DNA base composition, I analysed an exhaustive dataset of histone paralogous genes from human and mouse. I show that those gene copies that belong to subfamilies of very similar sequences (presumably undergoing gene conversion) have a higher GC content than unique gene copies (presumably not undergoing gene conversion). Thus, it seems that gene conversion is a biased process that tends to increase the DNA GC content, a conclusion that has implications for the evolution of isochores in vertebrates.

引用

页码：65 / 68

页数：4

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