Immortal strands? Give me a break

被引：146

作者：

Lansdorp, Peter M.

机构：

[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Dept Med, Div Hematol, Vancouver, BC V5Z 1L3, Canada

来源：

CELL | 2007年 / 129卷 / 07期

关键词：

D O I：

10.1016/j.cell.2007.06.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The "immortal strand" hypothesis proposes that asymmetrically dividing stem cells selectively retain chromosomes containing "old" DNA to prevent accumulation of mutations. As I describe in this Essay, such a possibility seems unlikely. An alternative explanation is that asymmetric cell divisions and cell fate are codirected by epigenetic differences between sister chromatids.

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页码：1244 / 1247

页数：4

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