Functional genomics of the paraoxonase (PON1) polymorphisms: Effects on pesticide sensitivity, cardiovascular disease, and drug metabolism

被引：206

作者：

Costa, LG ^{[1
]}

Cole, TB

Jarvik, GP

Furlong, CE

机构：

[1] Univ Washington, Dept Environm Hlth, Div Med Genet, Seattle, WA 98195 USA

[2] Univ Washington, Dept Genome Sci & Med, Div Med Genet, Seattle, WA 98195 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2003年 / 54卷

关键词：

metabolism of oxidized lipids; organophosphate metabolism; linkage disequilibrium; nerve agents; drug metabolism; statin metabolism;

D O I：

10.1146/annurev.med.54.101601.152421

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

This review focuses on the functional genomics of the human paraoxonase (PON1) polymorphisms. Levels and genetic variability of the PON1 position 192 isoforms (Gln/Arg) influence sensitivity to specific insecticides or nerve agents and risk for. cardiovascular disease. A more recent area of investigation, the role of PON1 in drug metabolism, is also discussed. We emphasize the importance of considering both PON1 isoforms and PON1 levels in disease/sensitivity association studies.

引用

页码：371 / 392

页数：22

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