Effects of estrogen replacement on choline acetyltransferase and trkA mRNA expression in the basal forebrain of aged rats

被引：31

作者：

Singer, CA

McMillan, PJ

Dobie, DJ

Dorsa, DM

机构：

[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA

[2] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[3] Dept Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Seattle, WA 98108 USA

来源：

BRAIN RESEARCH | 1998年 / 789卷 / 02期

关键词：

estrogen; aging; choline acetyltransferase; neurotrophins; trkA; basal forebrain;

D O I：

10.1016/S0006-8993(98)00142-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of one week of estrogen replacement on choline acetyltransferase (ChAT) and trkA mRNA expression are examined in young and aged rodents to determine whether estrogen continues to affect cholinergic neurons in aging brain. Significant increases in ChAT and trkA are observed in the nucleus basalis of Meynert (nBM) of both age groups. ChAT expression is also increased in the HDB without changes in trkA expression. Results indicate modulation of ChAT expression by estrogen is retained in the aged rodent brain and suggests the possibility that changes in ChAT expression may be dissociated from concurrent alterations in trkA. (C) 1998 Elsevier Science B.V.

引用

页码：343 / 346

页数：4

共 16 条

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[2] EFFECTS OF ESTROGEN REPLACEMENT ON THE RELATIVE LEVELS OF CHOLINE-ACETYLTRANSFERASE, TRKA, AND NERVE GROWTH-FACTOR MESSENGER-RNAS IN THE BASAL FOREBRAIN AND HIPPOCAMPAL-FORMATION OF ADULT-RATS [J].