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TWISTing an embryonic transcription factor into an oncoprotein

被引：140
作者：
Ansieau, S. [1 ]
Morel, A-P
Hinkal, G.
Bastid, J. [2 ]
Puisieux, A. [1 ,2 ]
机构：
[1] Ctr Leon Berard, INSERM, U590, F-69008 Lyon, France
[2] Univ Lyon 1, Inst Sci Pharmaceut & Biol, F-69365 Lyon, France
来源：
ONCOGENE | 2010年 / 29卷 / 22期
关键词：
TWIST; embryogenesis; EMT; failsafe program escape; cell dissemination; EPITHELIAL-MESENCHYMAL TRANSITION; SAETHRE-CHOTZEN-SYNDROME; HUMAN BREAST-CANCER; LYMPH-NODE METASTASIS; E-CADHERIN EXPRESSION; BHLH PROTEIN TWIST; GROWTH-FACTOR-BETA; HEPATOCELLULAR-CARCINOMA; UP-REGULATION; STEM-CELLS;
D O I：
10.1038/onc.2010.92
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the past decade, the reactivation of TWIST embryonic transcription factors has been described as a frequent event and a marker of poor prognosis in an impressive array of human cancers. Growing evidence now supports the premise that these cancers hijack TWIST's embryonic functions, granting oncogenic and metastatic properties. In this review, we report on the history and recent breakthroughs in understanding TWIST protein functions and the emerging role of the associated epithelial-mesenchymal transition (EMT) in tumorigenesis. We then broaden the discussion to address the general contribution of reactivating embryonic programs in cancerogenesis. Oncogene (2010) 29, 3173-3184; doi: 10.1038/onc.2010.92; published online 12 April 2010
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收藏
页码：3173 / 3184
页数：12
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