Low levels of 25-hydroxy vitamin D are associated with elevated parathyroid hormone in healthy adolescent females

被引:97
作者
Harkness, L
Cromer, B
机构
[1] Metrohlth Med Ctr, Dept Pediat, Div Adolescent Med, Cleveland, OH 44109 USA
[2] Case Western Reserve Univ, Sch Med, Cleveland, OH 44106 USA
关键词
adolescent; female; 25-hydroxyvitamin D; parathyroid hormone; vitamin D;
D O I
10.1007/s00198-004-1656-8
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
This study aimed to investigate the relationship between 25-hydroxyvitamin D [25(OH)D)] and parathyroid hormone (PTH) levels in adolescent females residing in a northern climate. Concern regarding vitamin D status in this population is due to limited sunlight exposure in northern latitudes, decreased outdoor recreational activities, as well as decreased conversion in black girls from increased skin pigmentation. In this cross-sectional analysis, serum samples were assayed for 25(OH)D using competitive protein binding (CPB) assay and PTH with immuno-radiometric (RIA) procedures. Four hundred postmenarcheal females (12-18 years) residing in northeastern Ohio were recruited. Subjects were excluded if they had a history of bone, kidney.. or liver disease, or used medications that affect bone. The primary goal was to determine serum 25(OH)D concentrations in relation to circulating PTH levels in a population of adolescent girls. The Spearman correlation test was used to compare PTH and 25(OH)D. Fit multiple split models were run to determine change in slope of the regression line when 25(OH)D and PTH were plotted. Analysis of variance was determined using modeled means with differences by race and season in the final model. Unadjusted mean serum 25(OH)D and PTH levels were 55.0 +/- 30.4 nmol/l and 39.4 +/- 20.6 ng/l, respectively. Blacks had lower 25(OH)D and higher PTH compared with non-blacks (P<0.0001), especially during the winter months. Decreasing 25(OH)D was inversely correlated with PTH (r = -0.314) (P < 0.0001), and at concentrations of 25(OH)D less than or equal to 90 nmol/l, an increase in PTH was observed. Adolescents are at risk for decreased serum 25(OH)D concentrations, especially black girls. We found that the widely used cutoff for vitamin D deficiency is associated with increasing PTH levels and is below the inflection point for a change in the slope of the regression line. Our results suppcirt the need for further research to establish optimal vitamin D status in adolescent girls.
引用
收藏
页码:109 / 113
页数:5
相关论文
共 22 条
[1]   Vitamin D and its major metabolites: Serum levels after graded oral dosing in healthy men [J].
Barger-Lux, MJ ;
Heaney, RP ;
Dowell, S ;
Chen, TC ;
Holick, MF .
OSTEOPOROSIS INTERNATIONAL, 1998, 8 (03) :222-230
[2]   EVIDENCE FOR ALTERATION OF THE VITAMIN-D-ENDOCRINE SYSTEM IN BLACKS [J].
BELL, NH ;
GREENE, A ;
EPSTEIN, S ;
OEXMANN, MJ ;
SHAW, S ;
SHARY, J .
JOURNAL OF CLINICAL INVESTIGATION, 1985, 76 (02) :470-473
[3]  
Calvo MS, 2003, NUTR REV, V61, P107, DOI 10.1301/nr.2003.marr.107-113
[4]   Prevalence of vitamin D insufficiency in an adult normal population [J].
Chapuy, MC ;
Preziosi, P ;
Maamer, M ;
Arnaud, S ;
Galan, P ;
Hercberg, S ;
Meunier, PJ .
OSTEOPOROSIS INTERNATIONAL, 1997, 7 (05) :439-443
[5]   Seasonal deficiency of vitamin D in children:: A potential target for osteoporosis-preventing strategies? [J].
Docio, S ;
Riancho, JA ;
Pérez, A ;
Olmos, JM ;
Amado, JA ;
González-Macías, J .
JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (04) :544-548
[6]  
Food and Nutrition Board of the Institute of Medicine, 1997, Dietary reference intakes for calcium, phosphorus, magnesium, vitamin D, fluoride, P250
[7]   Wintertime vitamin D deficiency in male adolescents:: Effect on parathyroid function and response to vitamin D3 supplements [J].
Guillemant, J ;
Le, HT ;
Maria, A ;
Allemandou, A ;
Pérès, G ;
Guillemant, S .
OSTEOPOROSIS INTERNATIONAL, 2001, 12 (10) :875-879
[8]   Vitamin D status during puberty in French healthy male adolescents [J].
Guillemant, J ;
Taupin, P ;
Le, HT ;
Taright, N ;
Allemandou, A ;
Pérès, G ;
Guillemant, S .
OSTEOPOROSIS INTERNATIONAL, 1999, 10 (03) :222-225
[9]  
Heaney RP, 1999, AM J CLIN NUTR, V69, P825
[10]   THE EFFECT OF VITAMIN-D SUPPLEMENTATION ON VITAMIN-D STATUS AND PARATHYROID FUNCTION IN ELDERLY SUBJECTS [J].
LIPS, P ;
WIERSINGA, A ;
VANGINKEL, FC ;
JONGEN, MJM ;
NETELENBOS, JC ;
HACKENG, WHL ;
DELMAS, PD ;
VANDERVIJGH, WJF .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1988, 67 (04) :644-650