Assembly of the monomer unit of bacterial peptidoglycan

被引：54

作者：

van Heijenoort, J ^{[1
]}

机构：

[1] Universite Paris Sud, F-91405 Orsay, France

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 1998年 / 54卷 / 04期

关键词：

bacterial peptidoglycan; precursor synthetases; catalytic mechanisms; regulations;

D O I：

10.1007/s000180050155

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The biosynthesis of peptidoglycan is a two-stage profess. The first stage concerns the endocellular assembly of its monomer unit, whereas the second one concerns the exocellular polymerization steps. The continued interest for this system is due to (i) the emergence of new resistance mechanisms: (ii) the need of specific targets in the search for new antibacterials; and (iii) the steady progress in the study of the correlation of peptidoglycan metabolism with cell growth and division. The various steps of the assembly of the monomer unit will be discussed as well as the correlations between the two Stages. Finally, the flexibility of the pathway will be exemplified in Escherichia coli and Staphylococcus aureus.

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页码：300 / 304

页数：5

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