Vitamin E inhibits IgE responses to allergic stimuli in animals. We investigated the relation between dietary vitamin 5 intake and serum IgE concentrations and atopy, measured as allergen skin sensitisation, in a random sample of 2633 adults. Higher concentrations of vitamin E intake were associated with lower serum IgE concentrations and a lower frequency of allergen sensitisation, These findings may explain the beneficial effect of dietary vitamin E on the incidence of asthma.