A norbornyl route to azasugars: stereoselective synthesis of isofagomine analogues

被引：21

作者：

Mehta, G ^{[1
]}

Mohal, N ^{[1
]}

机构：

[1] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 30期

关键词：

carbohydrate mimetics; enzyme inhibitors; piperidines; osmylation;

D O I：

10.1016/S0040-4039(00)00896-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A stereoselective synthesis of new isofagomine analogues has been achieved from a suitably functionalized cyclopentene intermediate extracted from the norbornyl framework. Double reductive amination or inter- and intramolecular N-alkylations are the key steps in constructing the piperidine ring. Isofagomine derivatives exhibit moderate inhibitory activity in enzyme assays. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5747 / 5751

页数：5

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