Does palmitoylation target estrogen receptors to plasma membrane caveolae?

被引：41

作者：

Acconcia, F ^{[1
]}

Bocedi, A ^{[1
]}

Ascenzi, P ^{[1
]}

Marino, M ^{[1
]}

机构：

[1] Univ Roma Tre, Dipartimento Biol, I-00146 Rome, Italy

来源：

IUBMB LIFE | 2003年 / 55卷 / 01期

关键词：

estrogen receptor; 17; beta-estradiol; caveolin; palmitoylation; plasma membrane localization;

D O I：

10.1080/1521654031000081256

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of transcriptional activity of the receptor and have been attributed to membrane ERs belonging to a signaling complex localized in caveolae. Here, we postulate that S-acylation of cysteine residue(s) present in the ligand binding domain of ERalpha and ERbeta may play a critical role in the membrane caveolar localization of the receptor and in the formation of the 'steroid signalosome'.

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页码：33 / 35

页数：3

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