Use of factor analysis to detect potential phenotypes in obsessive-compulsive disorder

被引:71
作者
Denys, D [1 ]
de Geus, F [1 ]
van Megen, HJGM [1 ]
Westenberg, HGM [1 ]
机构
[1] Univ Utrecht, Med Ctr, Dept Psychiat, NL-3508 GA Utrecht, Netherlands
关键词
obsessive-compulsive disorder; factor analysis; phenotypes; Y-BOCS;
D O I
10.1016/j.psychres.2003.11.005
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
This study aimed to identify symptom dimensions in obsessive-compulsive disorder (OCD) in order to reveal distinct clinical phenotypes. Factor analysis of the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) checklist on item level was performed on data from 335 outpatients with primary OCD. The relationship of demographic and clinical characteristics to the resulting factor scores was examined. A principal component analysis identified the following five consistent symptom dimensions: (1) contamination and cleaning, (2) aggressive, sexual and religious obsessions, (3) somatic obsessions and checking, (4) syrnmetry and counting/arranging compulsions and (5) high-risk assessment and checking. We observed significant differences in sex distribution, age of onset, Y-BOCS scores and familial prevalence of OCD in relation to the symptom dimensions. These findings provide further evidence for distinct clinical phenotypes in OCD. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:273 / 280
页数:8
相关论文
共 29 条
[1]  
Alsobrook JP, 1999, AM J MED GENET, V88, P669, DOI 10.1002/(SICI)1096-8628(19991215)88:6<669::AID-AJMG17>3.0.CO
[2]  
2-N
[3]  
BAER L, 1994, J CLIN PSYCHIAT, V55, P18
[4]  
BARTLETT MS, 1954, J ROY STAT SOC B, V16, P296
[5]   Obsessive-compulsive disorder subgroups: a symptom-based clustering approach [J].
Calamari, JE ;
Wiegartz, PS ;
Janeck, AS .
BEHAVIOUR RESEARCH AND THERAPY, 1999, 37 (02) :113-125
[6]   GENETIC AND ENVIRONMENTAL-INFLUENCES ON OBSESSIONAL TRAITS AND SYMPTOMS [J].
CLIFFORD, CA ;
MURRAY, RM ;
FULKER, DW .
PSYCHOLOGICAL MEDICINE, 1984, 14 (04) :791-800
[7]  
GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
[8]  
GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1012
[9]   A RATING SCALE FOR DEPRESSION [J].
HAMILTON, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62
[10]   THE ASSESSMENT OF ANXIETY-STATES BY RATING [J].
HAMILTON, M .
BRITISH JOURNAL OF MEDICAL PSYCHOLOGY, 1959, 32 (01) :50-55