Regulation of inositol lipid kinases by Rho and Rac

被引：79

作者：

Ren, XD ^{[1
]}

Schwartz, MA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Vasc Biol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(98)80063-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rho and Rac small GTPases associate with type-I phosphatidylinositol 4-phosphate 5-kinase to regulate the production of phosphatidylinositol 4,5-bisphosphate. This lipid appears to mediate some of the effects of Rho and Rac on the actin cytoskeleton. The genes for several type-I phosphatidylinositol 4-phosphate 5-kinases have been cloned recently but it is not known which one interacts with Rho and/or Rac. Rho family GTPases also interact with phosphatidylinositol 8-kinase, though this kinase can be either upstream or downstream of the GTPases depending upon the system.

引用

页码：63 / 67

页数：5

共 46 条

[1] Formation of actin stress fibers and focal adhesions enhanced by Rho-kinase [J].

Amano, M ;

Chihara, K ;

Kimura, K ;

Fukata, Y ;

Nakamura, N ;

Matsuura, Y ;

Kaibuchi, K .

SCIENCE, 1997, 275 (5304) :1308-1311

[2] Rac GTPase interacts specifically with phosphatidylinositol 3-kinase [J].

Bokoch, GM ;

Vlahos, CJ ;

Wang, Y ;

Knaus, UG ;

TraynorKaplan, AE .

BIOCHEMICAL JOURNAL, 1996, 315 :775-779

[3] THE SEQUENCE OF PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE DEFINES A NOVEL FAMILY OF LIPID KINASES [J].

BORONENKOV, IV ;

ANDERSON, RA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (07) :2881-2884

[4] A novel interaction between the juxtamembrane region of the p55 tumor necrosis factor receptor and phosphatidylinositol-4-phosphate 5-kinase [J].

Castellino, AM ;

Parker, GJ ;

Boronenkov, IV ;

Anderson, RA ;

Chao, MV .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (09) :5861-5870

[5] The Dbl family of oncogenes [J].

Cerione, RA ;

Zheng, Y .

CURRENT OPINION IN CELL BIOLOGY, 1996, 8 (02) :216-222

[6] THE SMALL GTP-BINDING PROTEIN-RHO REGULATES A PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE IN MAMMALIAN-CELLS [J].

CHONG, LD ;

TRAYNORKAPLAN, A ;

BOKOCH, GM ;

SCHWARTZ, MA .

CELL, 1994, 79 (03) :507-513

[7] THE CLONING AND SEQUENCE OF THE C-ISOFORM OF PTDINS4P 5-KINASE [J].

DIVECHA, N ;

TRUONG, O ;

HSUAN, JJ ;

HINCHLIFFE, KA ;

IRVINE, RF .

BIOCHEMICAL JOURNAL, 1995, 309 :715-719

[8] Escherichia coli cytotoxic necrotizing factor 1 (CNF1), a toxin that activates the Rho GTPase [J].

Fiorentini, C ;

Fabbri, A ;

Flatau, G ;

Donelli, G ;

Matarrese, P ;

Lemichez, E ;

Falzano, L ;

Boquet, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) :19532-19537

[9] THE PROTEIN-KINASE ENCODED BY THE AKT PROTOONCOGENE IS A TARGET OF THE PDGF-ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE [J].

FRANKE, TF ;

YANG, SI ;

CHAN, TO ;

DATTA, K ;

KAZLAUSKAS, A ;

MORRISON, DK ;

KAPLAN, DR ;

TSICHLIS, PN .

CELL, 1995, 81 (05) :727-736

[10] Regulation of vinculin binding to talin and actin by phosphatidyl-inositol-4-5-bisphosphate [J].

Gilmore, AP ;

Burridge, K .

NATURE, 1996, 381 (6582) :531-535

← 1 2 3 4 5 →