An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo development

被引：130

作者：

Deprost, D

Truong, HN

Robaglia, C

Meyer, C ^{[1
]}

机构：

[1] INRA, Ctr Versailles, Unite Nutr Azotee Plantes, F-78026 Versailles, France

[2] Fac Sci Luminy, Lab Genet & Biophys Plantes, F-13288 Marseille 9, France

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 326卷 / 04期

关键词：

Arabidopsis; AtTOR; embryo; KOG1; rapamycin; RAPTOR;

D O I：

10.1016/j.bbrc.2004.11.117

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The RAPTOR/KOG1 proteins are binding partners of the target of rapamycin kinase that is present in all eucaryotes and plays a central role in the stimulation of cell growth and metabolism in response to nutrients. We show in this report that two genes are coding for RAPTOR/KOG1 homologs in the Arabidopsis and rice genomes. Disruption of the Arabidopsis AtRaptor1 gene leads to a very early arrest of embryo development whereas disruption of the AtRaptor2 gene, which is expressed at a lower level than AtRaptor1, has no visible effects on embryo and plant development. We also observed that mutations in the AtRaptor1 gene result in an earlier halt of embryo development than disruption of the AtTor gene. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：844 / 850

页数：7

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