Imprinted gene in postnatal growth role

被引：80

作者：

Itier, JM ^{[1
]}

Tremp, GL

Léonard, JF

Multon, MC

Ret, G

Schweighoffer, F

Tocqué, B

Bluet-Pajot, MT

Cormier, V

Dautry, F

机构：

[1] Rhone Poulenc Rorer, Ctr Rech Vitry Alfortville, Vitry Sur Seine, France

[2] Ctr Paul Broca, INSERM, U159, Paris, France

[3] Hop Necker Enfants Malad, INSERM, U393, Unite Rech Handicaps Genet Enfant, Paris, France

[4] Inst Rech Canc, CNRS, UPR 9044, Villejuif, France

来源：

NATURE | 1998年 / 393卷 / 6681期

关键词：

D O I：

10.1038/30120

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mice that have been specially bred to lack a protein known as Grf-1, which is normally found only in the brain, do not grow properly after they are born and remain small all their lives. We have now identified a function of Grf-1 as an important regulator of the synthesis and release of growth hormone. Moreover, grf1, the gene encoding this protein, is unlike other imprinted genes that affect growth because it operates after, rather than before, birth.

引用

页码：125 / 126

页数：2

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