Large-scale identification in yeast of conserved ageing genes

被引：60

作者：

Kaeberlein, M

Kennedy, BK

机构：

[1] Univ Washington, Dept Biochem, Seattle, WA 98195 USA

[2] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

[3] Univ Washington, Dept Med, Seattle, WA 98195 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2005年 / 126卷 / 01期

关键词：

yeast aging; replicative life span; genome-wide; calorie restriction; Sir2; LIFE-SPAN EXTENSION; CALORIE RESTRICTION; SACCHAROMYCES-CEREVISIAE; DIETARY RESTRICTION; CELL-SURVIVAL; LONGEVITY; STRESS; SIR2; TRANSCRIPTION; NAD;

D O I：

10.1016/j.mad.2004.09.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances have suggested the existence of phylogenetically conserved pathways regulating ageing in eukaryotes. At least two of these "public" longevity-determining pathways appear to have been evolutionarily conserved from yeast through mammals. We have developed a high-throughput. genome-wide approach to identify a large fraction of the non-essential. single-gene deletion mutations that confer increased longevity in yeast. The identification and characterization of conserved genes that regulate the ageing process across eukaryotic species is likely to result in an improved understanding of the causes of human ageing and provide potential therapeutic targets for drug discovery. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：17 / 21

页数：5

相关论文

共 32 条

[1] Yeast life-span extension by calorie restriction is independent of NAD fluctuation [J].

Anderson, RM ;

Latorre-Esteves, M ;

Neves, AR ;

Lavu, S ;

Medvedik, O ;

Taylor, C ;

Howitz, KT ;

Santos, H ;

Sinclair, DA .

SCIENCE, 2003, 302 (5653) :2124-2126

[2] Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae [J].

Anderson, RM ;

Bitterman, KJ ;

Wood, JG ;

Medvedik, O ;

Sinclair, DA .

NATURE, 2003, 423 (6936) :181-185

[3] Longevity - Extending the lifespan of long-lived mice [J].

Bartke, A ;

Wright, JC ;

Mattison, JA ;

Ingram, DK ;

Miller, RA ;

Roth, GS .

NATURE, 2001, 414 (6862) :412-412

[4] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[5] Diversity in the Sir2 family of protein deacetylases [J].

Buck, SW ;

Gallo, CM ;

Smith, JS .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (06) :939-950

[6] Dietary restriction in long-lived dwarf flies [J].

Clancy, DJ ;

Gems, D ;

Hafen, E ;

Leevers, SJ ;

Partridge, L .

SCIENCE, 2002, 296 (5566) :319-319

[7] Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase [J].

Cohen, HY ;

Miller, C ;

Bitterman, KJ ;

Wall, NR ;

Hekking, B ;

Kessler, B ;

Howitz, KT ;

Gorospe, M ;

de Cabo, R ;

Sinclair, DA .

SCIENCE, 2004, 305 (5682) :390-392

[8] Rates of behavior and aging specified by mitochondrial function during development [J].

Dillin, A ;

Hsu, AL ;

Arantes-Oliveira, NA ;

Lehrer-Graiwer, J ;

Hsin, H ;

Fraser, AG ;

Kamath, RS ;

Ahringer, J ;

Kenyon, C .

SCIENCE, 2002, 298 (5602) :2398-2401

[9] Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae [J].

Fabrizio, P ;

Pletcher, SD ;

Minois, N ;

Vaupel, JW ;

Longo, VD .

FEBS LETTERS, 2004, 557 (1-3) :136-142

[10] Regulation of longevity and stress resistance by Sch9 in yeast [J].

Fabrizio, P ;

Pozza, F ;

Pletcher, SD ;

Gendron, CM ;

Longo, VD .

SCIENCE, 2001, 292 (5515) :288-290

← 1 2 3 4 →