Does endogenous 5-HT mediate spontaneous rhythmic activity in chemoreceptor clusters of rat carotid body?

被引：36

作者：

Zhang, M ^{[1
]}

Nurse, CA ^{[1
]}

机构：

[1] McMaster Univ, Dept Biol, Hamilton, ON L8S 4K1, Canada

来源：

BRAIN RESEARCH | 2000年 / 872卷 / 1-2期

基金：

英国医学研究理事会;

关键词：

type; 1; cell; cell culture; hypoxia; 5-HT receptors; ketanserin;

D O I：

10.1016/S0006-8993(00)02499-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Spontaneous voltage fluctuations often occurred during perforated-patch recordings from clustered rat carotid body (CB) chemoreceptors in vitro. This activity sometimes appeared as rhythmic-like spikes, when cluster size exceeded similar to 20 cells. Spike discharge could be augmented or induced by hypoxia or 5-HT (2-10 mu M) application, and inhibited by the 5-HT receptor blocker, ketanserin (50-100 mu M). Thus, endogenous 5-HT may contribute to spontaneous firing within CB receptor clusters via autocrine/paracrine mechanisms. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：199 / 203

页数：5

共 19 条

[1] ELECTRICAL COUPLING BETWEEN CULTURED GLOMUS CELLS OF THE RAT CAROTID-BODY - OBSERVATIONS WITH CURRENT AND VOLTAGE CLAMPING [J].