Polarity in the rabbit embryo

被引：21

作者：

Idkowiak, J

Weisheit, G

Viebahn, C

机构：

[1] Univ Gottingen, Dept Anat & Embryol, D-37075 Gottingen, Germany

[2] Univ Bonn, Dept Anat Anat & Cell Biol, D-53115 Bonn, Germany

[3] Univ Halle Wittenberg, Dept Anat & Cell Biol, D-06097 Halle An Der Saale, Germany

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2004年 / 15卷 / 05期

关键词：

gastrulation; anterior marginal crescent; primitive streak; hypoblast; left-right axis;

D O I：

10.1016/j.semcdb.2004.04.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The main aim of the gastrulation process is commonly regarded to be the generation of the definitive germ layers known as mesoderm, endoderm and ectoderm. Here we discuss how the topography of gene expression, cellular migration and proliferative activity in the preliminary germ layers (hypoblast and epiblast) of the rabbit embryo reveal the sequence of events that establishes the three major body axes. We present a testable model in which a combination of cellular movement in the hypoblast with a morphogen gradient created by the (extraembryonic) trophoblast creates morphological polarity in the embryo and, hence, the co-ordinates for germ layer formation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：607 / 617

页数：11

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