Cancer epigenomics: DNA methylomes and histone-modification maps

被引：1545

作者：

Esteller, Manel ^{[1
]}

机构：

[1] CNIO, Canc Energet Lab, Spanish Natl Canc Ctr, Madrid 28029, Spain

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 04期

关键词：

D O I：

10.1038/nrg2005

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis; among their results has been the seminal finding of transcriptional silencing of tumour-suppressor genes by CpG-island-promoter hypermethylation. However, recent technological advances are now allowing cancer epigenetics to be studied genome-wide-an approach that has already begun to provide both biological insight and new avenues for translational research. It is time to 'upgrade' cancer epigenetics research and put together an ambitious plan to tackle the many unanswered questions in this field using epigenomics approaches.

引用

页码：286 / 298

页数：13

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