Cellular Heterogeneity: Do Differences Make a Difference?

被引：861

作者：

Altschuler, Steven J. ^{[1
]}

Wu, Lani F. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Simmons Canc Ctr, Green Ctr Syst Biol, Dept Pharmacol, Dallas, TX 75390 USA

来源：

CELL | 2010年 / 141卷 / 04期

关键词：

STOCHASTIC GENE-EXPRESSION; CONTEXT; NOISE; IDENTIFICATION; ARCHITECTURE; VARIABILITY; SWITCH; MODEL;

D O I：

10.1016/j.cell.2010.04.033

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A central challenge of biology is to understand how individual cells process information and respond to perturbations. Much of our knowledge is based on ensemble measurements. However, cell-to-cell differences are always present to some degree in any cell population, and the ensemble behaviors of a population may not represent the behaviors of any individual cell. Here, we discuss examples of when heterogeneity cannot be ignored and describe practical strategies for analyzing and interpreting cellular heterogeneity.

引用

收藏

页码：559 / 563

页数：5

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