Subtrochanteric Femoral Fractures in Patients Receiving Long-Term Alendronate Therapy: Imaging Features

被引:33
作者
Chan, Sarah Shock [1 ]
Rosenberg, Zehava Sadka [1 ]
Chan, Keith [2 ]
Capeci, Craig [2 ]
机构
[1] NYU, Hosp Joint Dis, Dept Radiol, New York, NY 10009 USA
[2] NYU, Dept Orthoped, Hosp Joint Dis, New York, NY 10009 USA
关键词
alendronate; fracture; trauma; SUPPRESSED BONE TURNOVER; MICRODAMAGE ACCUMULATION; POSTMENOPAUSAL WOMEN; STRESS-FRACTURES; SHAFT FRACTURES; BISPHOSPHONATES; OSTEOPOROSIS; OSTEONECROSIS; COMPLICATION; TRIAL;
D O I
10.2214/AJR.09.3588
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
100231 [临床病理学]; 100902 [航空航天医学];
摘要
OBJECTIVE. A paradoxical association between long-term alendronate therapy and low-energy subtrochanteric femoral fractures has been recently recognized. A retrospective review of 34 such femoral fractures was performed. CONCLUSION. Subtrochanteric femoral fractures associated with long-term alendronate therapy present with minimal trauma, may be chronic, and when incomplete may be missed. The characteristic imaging features include initial involvement and focal thickening of the lateral cortex, transverse orientation, medial beak, and superior displacement and varus angulation at the fracture site.
引用
收藏
页码:1581 / 1586
页数:6
相关论文
共 24 条
[1]
Suppressed bone turnover during alendronate therapy for high-turnover osteoporosis [J].
Armamento-Villareal, Reina ;
Napoli, Nicola ;
Panwar, Vinita ;
Novack, Deborah .
NEW ENGLAND JOURNAL OF MEDICINE, 2006, 355 (19) :2048-2050
[2]
Fracture risk reduction with alendronate in women with osteoporosis: The Fracture Intervention Trial [J].
Black, DM ;
Thompson, DE ;
Bauer, DC ;
Ensrud, K ;
Musliner, T ;
Hochberg, MC ;
Nevitt, MC ;
Suryawanshi, S ;
Cummings, SR .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (11) :4118-4124
[3]
Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures [J].
Black, DM ;
Cummings, SR ;
Karpf, DB ;
Cauley, JA ;
Thompson, DE ;
Nevitt, MC ;
Bauer, DC ;
Genant, HK ;
Haskell, WL ;
Marcus, R ;
Ott, SM ;
Torner, JC ;
Quandt, SA ;
Reiss, TF ;
Ensrud, KE .
LANCET, 1996, 348 (9041) :1535-1541
[4]
Ten years' experience with alendronate for osteoporosis in postmenopausal women [J].
Bone, HG ;
Hosking, D ;
Devogelaer, J ;
Tucci, JR ;
Emkey, RD ;
Tonino, RP ;
Rodriguez-Portales, JA ;
Downs, RW ;
Gupta, J ;
Santora, AC ;
Liberman, UA .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (12) :1189-1199
[5]
Bush LA, 2008, RADIOL CASE REP, V3, P1
[6]
BUSH LA, 2009, RADIOL CASE REP, V4, P1
[7]
Bilateral Low-Energy Simultaneous or Sequential Femoral Fractures in Patients on Long-Term Alendronate Therapy [J].
Capeci, Craig M. ;
Tejwani, Nirmal C. .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2009, 91A (11) :2556-2561
[8]
Cheung Ralph K. H., 2007, Hong Kong Medical Journal, V13, P485
[9]
Subtrochanteric insufficiency fractures in patients on alendronate therapy - A caution [J].
Goh, S.-K. ;
Yang, K. Y. ;
Koh, J. S. B. ;
Wong, M. K. ;
Chua, S. Y. ;
Chua, D. T. C. ;
Howe, T. S. .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2007, 89B (03) :349-353
[10]
Iwamoto Jun, 2002, J Orthop Sci, V7, P707, DOI 10.1007/s007760200126