Mycobacterial virulence and specialized secretion: same story, different ending

被引：19

作者：

Behr, Marcel A.

Sherman, David R.

机构：

[1] McGill Univ, Ctr Hlth, Montreal, PQ H3G 1A4, Canada

[2] McGill Univ, Montreal Gen Hosp, Div Infect Dis & Med Microbiol, Montreal, PQ H3G 1A4, Canada

[3] Seattle Biomed Res Inst, Seattle, WA 98109 USA

[4] Univ Washington, Dept Pathol, Seattle, WA 98109 USA

来源：

NATURE MEDICINE | 2007年 / 13卷 / 03期

关键词：

D O I：

10.1038/nm0307-286

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genomic region lost during the attenuation of BCG vaccine encodes a newly discovered secretion system conserved among gram-positive bacteria. A series of papers has now dissected the components of this system, revealing a unique Mycobacterium tuberculosis-specific signal for export of bacterial proteins into the host.

引用

收藏

页码：286 / 287

页数：2

相关论文

共 16 条

[1] Comparative genomics of BCG vaccines by whole-genome DNA microarray [J].

Behr, MA ;

Wilson, MA ;

Gill, WP ;

Salamon, H ;

Schoolnik, GK ;

Rane, S ;

Small, PM .

SCIENCE, 1999, 284 (5419) :1520-1523

[2] Bacterial artificial chromosome-based comparative genomic analysis identifies Mycobacterium microti as a natural ESAT-6 deletion mutant [J].

Brodin, P ;

Eiglmeier, K ;

Marmiesse, M ;

Billault, A ;

Garnier, T ;

Niemann, S ;

Cole, ST ;

Brosch, R .

INFECTION AND IMMUNITY, 2002, 70 (10) :5568-5578

[3] C-terminal signal sequence promotes virulence factor secretion in Mycobacterium tuberculosis [J].

Champion, Patricia A. DiGiuseppe ;

Stanley, Sarah A. ;

Champion, Matthew M. ;

Brown, Eric J. ;

Cox, Jeffery S. .

SCIENCE, 2006, 313 (5793) :1632-1636

[4] Mutually dependent secretion of proteins required for mycobacterial virulence [J].

Fortune, SM ;

Jaeger, A ;

Sarracino, DA ;

Chase, MR ;

Sassetti, CM ;

Sherman, DR ;

Bloom, BR ;

Rubin, EJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (30) :10676-10681

[5] Individual RD1-region genes are required for export of ESAT-6/CFP-10 and for virulence of Mycobacterium tuberculosis [J].

Guinn, KM ;

Hickey, MJ ;

Mathur, SK ;

Zakel, KL ;

Grotzke, JE ;

Lewinsohn, DM ;

Smith, S ;

Sherman, DR .

MOLECULAR MICROBIOLOGY, 2004, 51 (02) :359-370

[6] The primary mechanism of attenuation of bacillus Calmette-Guerin is a loss of secreted lytic function required for invasion of lung interstitial tissue [J].

Hsu, T ;

Hingley-Wilson, SM ;

Chen, B ;

Chen, M ;

Dai, AZ ;

Morin, PM ;

Marks, CB ;

Padiyar, J ;

Goulding, C ;

Gingery, M ;

Eisenberg, D ;

Russell, RG ;

Derrick, SC ;

Collins, FM ;

Morris, SL ;

King, CH ;

Jacobs, WR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (21) :12420-12425

[7] Deletion of RD1 from Mycobacterium tuberculosis mimics bacille Calmette-Guerin attenuation [J].

Lewis, KN ;

Liao, RL ;

Guinn, KM ;

Hickey, MJ ;

Smith, S ;

Behr, MA ;

Sherman, DR .

JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (01) :117-123

[8] A non-RD1 gene cluster is required for Snm secretion in Mycobacterium tuberculosis [J].

MacGurn, JA ;

Raghavan, S ;

Stanley, SA ;

Cox, JS .

MOLECULAR MICROBIOLOGY, 2005, 57 (06) :1653-1663

[9] Molecular analysis of genetic differences between Mycobacterium bovis BCG and virulent M-bovis [J].

Mahairas, GG ;

Sabo, PJ ;

Hickey, MJ ;

Singh, DC ;

Stover, CK .

JOURNAL OF BACTERIOLOGY, 1996, 178 (05) :1274-1282

[10] Genomic interrogation of the dassie bacillus reveals it as a unique RD1 mutant within the Mycobacterium tuberculosis complex [J].

Mostowy, S ;

Cousins, D ;

Behr, MA .

JOURNAL OF BACTERIOLOGY, 2004, 186 (01) :104-109