Application of a Fas ligand encoding a recombinant adenovirus vector for prolongation of transgene expression

被引：33

作者：

Zhang, HG

Bilbao, G

Zhou, T

Contreras, JL

Gómez-Navarro, J

Feng, MZ

Saito, I

Mountz, JD

Curiel, DT

机构：

[1] Univ Alabama, Gene Therapy Program, Dept Rheumatol, Birmingham, AL 35294 USA

[2] Univ Alabama, Gene Therapy Program, Dept Surg, Birmingham, AL 35294 USA

[3] Univ Tokyo, Inst Med Sci, Genet Mol Lab, Tokyo, Japan

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 03期

关键词：

D O I：

10.1128/JVI.72.3.2483-2490.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

An adenovirus vector encoding murine Fas ligand (mFasL) under an inducible control was derived. In vivo ectopic expression of mFasL in murine livers induced an inflammatory cellular infiltration. Furthermore, ectopic expression of mFasL by myocytes did not allow prolonged vector-mediated transgene expression. Thus, ectopic expression of functional mFasL in vector-transduced cells does not appear to confer, by itself, an immunoprivileged site sufficient to mitigate adenovirus vector immunogenicity.

引用

页码：2483 / 2490

页数：8

共 66 条

[1]

ACSADI G, 1995, J MOL MED, V73, P165

[2] Dystrophin expression in muscles of mdx mice after adenovirus-mediated in vivo gene transfer [J].