Structure of the house dust mite allergen Der f 2: Implications for function and molecular basis of IgE cross-reactivity

被引：44

作者：

Johannessen, BR

Skov, LK

Kastrup, JS

Kristensen, O

Bolwig, C

Larsen, JN

Spangfort, M

Lund, K

Gajhede, M

机构：

[1] Danish Univ Pharmaceut Sci, Dept Med Chem, DK-2100 Copenhagen, Denmark

[2] ALK Abello, DK-2970 Horsholm, Denmark

来源：

FEBS LETTERS | 2005年 / 579卷 / 05期

关键词：

Dermatophagoides farinae group 2 major allergen; cross-reacting epitope; hydrophobic cavity; lipid binding;

D O I：

10.1016/j.febslet.2004.11.115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The X-ray structure of the group 2 major allergen from Dermatophagoides farinae (Der f 2) was determined to 1.83 Angstrom resolution. The overall Der f 2 structure comprises a single domain of immunoglobulin fold with two anti-parallel beta-sheets. A large hydrophobic cavity is formed in the interior of Der f 2. Structural comparisons to distantly related proteins suggest a role in lipid binding. Immunoglobulin E (IgE) cross-reactivity between group 2 house dust mite major allergens can be explained by conserved surface areas representing IgE binding epitopes. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：1208 / 1212

页数：5

相关论文

共 30 条

[1] THE CCP4 SUITE - PROGRAMS FOR PROTEIN CRYSTALLOGRAPHY [J].

BAILEY, S .

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 1994, 50 :760-763

[2] ALLERGIC RESPIRATORY-DISEASE IN GRAIN WORKERS - THE ROLE OF STORAGE MITES [J].

BLAINEY, AD ;

TOPPING, MD ;

OLLIER, S ;

DAVIES, RJ .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1989, 84 (03) :296-303

[3]

Brunger AT, 1998, ACTA CRYSTALLOGR D, V54, P905, DOI 10.1107/s0907444998003254

[4] BARN ALLERGY - ASTHMA AND RHINITIS DUE TO STORAGE MITES [J].

CUTHBERT, OD ;

BROSTOFF, J ;

WRAITH, DG ;

BRIGHTON, WD .

CLINICAL ALLERGY, 1979, 9 (03) :229-236

[5]

DELANO WL, 2002, PYMOL MOL GRAPHICS

[6] The crystal structure of a major dust mite allergen Der p 2, and its biological implications [J].

Derewenda, U ;

Li, J ;

Derewenda, Z ;

Dauter, Z ;

Mueller, GA ;

Rule, GS ;

Benjamin, DC .

JOURNAL OF MOLECULAR BIOLOGY, 2002, 318 (01) :189-197

[7] Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease [J].

Friedland, N ;

Liou, HL ;

Lobel, P ;

Stock, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2512-2517

[8] Cross-reactivity studies of a new group 2 allergen from the dust mite Glycyphagus domesticus, Gly d 2, and group 2 allergens from Dermatophagoides pteronyssinus, Lepidoglyphus destructor, and Tyrophagus putrescentiae with recombinant allergens [J].

Gafvelin, G ;

Johansson, E ;

Lundin, A ;

Smith, AM ;

Chapman, MD ;

Benjamin, DC ;

Derewenda, U ;

van Hage-Hamsten, M .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 107 (03) :511-518

[9] PDB file parser and structure class implemented in Python']Python [J].

Hamelryck, T ;

Manderick, B .

BIOINFORMATICS, 2003, 19 (17) :2308-2310

[10] Structure of the Rho family GTP-binding protein Cdc42 in complex with the multifunctional regulator RhoGDI [J].

Hoffman, GR ;

Nassar, N ;

Cerione, RA .

CELL, 2000, 100 (03) :345-356