The role of complement in Alzheimer's disease pathology
被引:81
作者:
Emmerling, MR
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USA
Emmerling, MR
[1
]
Watson, MD
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机构:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USA
Watson, MD
[1
]
Raby, CA
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机构:
Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USA
Raby, CA
[1
]
Spiegel, K
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Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USAWarner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USA
Spiegel, K
[1
]
机构:
[1] Warner Lambert Parke Davis, Parke Davis Pharmaceut Res Div, Neurosci Therapeut, Ann Arbor, MI 48106 USA
来源:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
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2000年
/
1502卷
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01期
Complement proteins are integral components of amyloid plaques and cerebral vascular amyloid ill Alzheimer brains. They can be found at the earliest stages of amyloid deposition and their activation coincides with the clinical expression of Alzheimer's dementia. This review will examine the origins of complement in the brain and the role of P-amyloid peptide (AP) in complement activation in Alzheimer's disease, an event that might serve as a nidus of chronic inflammation. Pharmacology therapies that may serve to inhibit A beta-mediated complement activation will also be discussed. (C) 2000 Elsevier Science B.V. All rights reserved.