Proton transfer in the solid state: Reactions of organic acids and amines

Grinding of crystalline organic acids and amines leads to proton transfer with ammonium salt formation or to hydrogen bonded complexes. Formation of amides is not achieved with these reagents even under strong impact. The mechanochemical processes were monitored by IR spectroscopy. Thirteen acids and four amines covering a wide range of acidity, basicity and hardness were employed.