Long Noncoding RNA MEG3 Negatively Regulates Proliferation and Angiogenesis in Vascular Endothelial Cells

被引：116

作者：

He, Chao ^{[1
]}

Yang, Wei ^{[1
]}

Yang, Jun ^{[1
]}

Ding, Jiawang ^{[1
]}

Li, Song ^{[1
]}

Wu, Hui ^{[1
]}

Zhou, Fei ^{[1
]}

Jiang, Yurong ^{[1
]}

Teng, Lin ^{[1
]}

Yang, Jian ^{[1
]}

机构：

[1] China Three Gorges Univ, Inst Cardiol, 183 Yiling Rd, Yichang 443003, Hubei Province, Peoples R China

来源：

DNA AND CELL BIOLOGY | 2017年 / 36卷 / 06期

基金：

中国国家自然科学基金;

关键词：

lncRNA; MEG3; angiogenesis; miR-9; COMPETING ENDOGENOUS RNA; GASTRIC-CANCER; MIGRATION; EXPRESSION; APOPTOSIS; INVASION; DISEASE; GROWTH;

D O I：

10.1089/dna.2017.3682

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Long noncoding RNA (lncRNA) MEG3 is an important tumor suppressor in several types of human cancers. However, the biological function and underlying mechanism of MEG3 in vascular endothelial cells (VECs) remain unknown. In the present study, we demonstrated the functional importance of lncRNA MEG3 in proliferation and angiogenesis of VECs. MEG3 overexpression significantly suppressed the proliferation and in vitro angiogenesis in VECs, whereas knockdown of MEG3 had the opposite effect. Furthermore, we found that MEG3 exerts its function through negatively regulating miR-9 by acting as a microRNA sponge. Taken together, MEG3-miR-9 plays an important role in proliferation and angiogenesis in VECs.

引用

收藏

页码：475 / 481

页数：7

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