High-density lipoprotein cholesterol and triglyceride response with simvastatin versus atorvastatin in familial hypercholesterolemia

被引：22

作者：

Wierzbicki, AS ^{[1
]}

Lumb, PJ ^{[1
]}

Chik, G ^{[1
]}

Crook, MA ^{[1
]}

机构：

[1] Kings Coll London, Guys Kings & St Thomas Med Sch, Dept Chem Pathol, London WC2R 2LS, England

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2000年 / 86卷 / 05期

关键词：

D O I：

10.1016/S0002-9149(00)01012-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The clinical and biochemical determinants of high-density lipoprotein (HDL) and triglyceride response to simvastatin and atorvastatin were assessed in 150 patients with severe hyperlipidemia treated in a randomized open-trial format design. Triglyceride reduction was only dependent on HDL:apolipoprotein Al, change in apolipoprotein B, and dose response, whereas an increase in HDL was dependent on initial LDL, change in LDL or dose response, and therapy with simvastatin.

引用

页码：547 / +

页数：4

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