Cytotoxic neolignans: an SAR study

被引：71

作者：

Kong, ZL ^{[1
]}

Tzeng, SC ^{[1
]}

Liu, YC ^{[1
]}

机构：

[1] Natl Taiwan Ocean Univ, Dept Food Sci, Chilung, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 01期

关键词：

neolignans; cytotoxicities; Hep-G2; SAR;

D O I：

10.1016/j.bmcl.2004.10.011

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The neolignans, magnolol 1 and honokiol 2 have been reported to inhibit the growth of several tumor cell lines in vitro and in vivo. The chemical structure of magnolol and honokiol consists of biphenyl skeleton with phenolic and allylic functionalities. Analogs of 1 and 2 containing different substitution have been studies for their effect on the growth of Hep-G2 and their structure-activity relationships were reported in this work. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：163 / 166

页数：4

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