Lithium addition in antidepressant-resistant depression:: Effects on platelet 5-HT, plasma 5-HT and plasma 5-HIAA concentration

被引：9

作者：

Birkenhager, Tom K.

van den Broek, Walter W.

Fekkes, Durk

Mulder, Paul G.

Moleman, Peter

Bruijn, Jan A.

机构：

[1] Erasmus MC, Dept Psychiat, NL-3000 CA Rotterdam, Netherlands

[2] Erasmus MC, Dept Neurosci, Rotterdam, Netherlands

[3] Erasmus MC, Dept Biostat & Epidemiol, Rootstown, OH USA

[4] Moleman Psychopharmacol, Amerongen, Netherlands

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2007年 / 31卷 / 05期

关键词：

lithium addition; major depression; plasma; 5-HIAA; 5-HT; platelet;

D O I：

10.1016/j.pnpbp.2007.03.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The efficacy of the addition of lithium to an established course of antidepressant treatment can be explained by a synergistic effect of the two drugs on central 5-HT neurotransmission. In the present study we investigated the effect of lithium addition on the 5-HT concentration in plasma and platelets and the concentration of 5-HIAA. Thirty-nine depressed inpatients who fulfilled the DSM-IV criteria for major depressive disorder and who did not respond to monotherapy with either imipramine or fluvoxamine participated in this study. Concentration of 5-HT in both plasma and platelets did not change significantly during lithium addition. The 5-HT ratio (plasma concentration/platelet concentration) shows a small nonsignificant increase after 3 weeks lithium addition. The mean concentration of 5-HIAA shows a significant increase during lithium addition; with no difference between the imipramine and the fluvoxamine sample. The increments in 5-HIAA concentration during lithium addition are indicative of an increased 5-HT turnover. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：1084 / 1088

页数：5

共 22 条

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