Synthesis of the bisbenzannelated spiroketal core of the γ-rubromycins.: The use of a novel Nef-type reaction mediated by Pearlman's catalyst

被引：46

作者：

Capecchi, T ^{[1
]}

de Koning, CB ^{[1
]}

Michael, JP ^{[1
]}

机构：

[1] Univ Witwatersrand, Dept Chem, Ctr Mol Design, ZA-2050 Witwatersrand, South Africa

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 2000年 / 16期

关键词：

D O I：

10.1039/b002984j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the bisbenzannelated spiroketal core 6 of the gamma-rubromycin 1 from the substituted nitrostyrene 20 was achieved by using a novel Nef-type reaction mediated by Pearlman's catalyst. The precursor 28 was synthesised from readily prepared starting materials using Henry condensation chemistry. The product 6 was found to exist in two conformations in solution as shown by NMR spectroscopy.

引用

页码：2681 / 2688

页数：8

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