An easy entry to (1S, 2S) and (1R, 2R)-threo-ifenprodil

被引：4

作者：

Mantegani, S ^{[1
]}

Arlandini, E ^{[1
]}

Brambilla, E ^{[1
]}

Cremonesi, P ^{[1
]}

Varasi, M ^{[1
]}

机构：

[1] Pharmacia & Upjohn Inc, Dept Chem, Discovery Res Oncol, I-20014 Nerviano, MI, Italy

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 19期

关键词：

D O I：

10.1080/00397910008087268

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and practical synthesis of enantiomerically pure (L) or (D)-threo-Ifenprodil was accomplished from (1S, 2S)- and (1R, 2R)-threo-1-(p-nitrophenyl)-2-amino-propan-1 3-diol via 3-phenylthio derivatives followed by Raney nickel reduction and conversion of the aromatic amine into phenol.

引用

页码：3543 / 3553

页数：11

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