The assembly of the factor X-activating complex on activated human platelets

被引:54
作者
Ahmad, SS
London, FS
Walsh, PN
机构
[1] Temple Univ, Sch Med, Sol Sherry Thrombosis Res Ctr, Philadelphia, PA 19140 USA
[2] Temple Univ, Sch Med, Dept Biochem, Philadelphia, PA 19140 USA
[3] Temple Univ, Sch Med, Dept Med, Philadelphia, PA 19140 USA
关键词
agonists; factor IXa; factor VIIIa; factor X activation; factor X; platelet membrane receptors; platelets; prothrombin;
D O I
10.1046/j.1538-7836.2003.00020.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Platelet membranes provide procoagulant surfaces for the assembly and expression of the factor X-activating complex and promote the proteolytic activation and assembly of the prothrombinase complex resulting in normal hemostasis. Recent studies from our laboratory and others indicate that platelets possess specific, high-affinity, saturable, receptors for factors XI, XIa, IX, IXa, X, VIII, VIIIa, V, Va and Xa, prothrombin, and thrombin. Studies described in this review support the hypothesis that the factor X-activating complex on the platelet surface consists of three receptors (for the enzyme, factor IXa; the substrate, factor X; and the cofactor, factor VIIIa), the colocalization of which results in a 24 million-fold acceleration of the rate of factor X activation. Whether the procoagulant surface of platelets is defined exclusively by procoagulant phospholipids, or whether specific protein receptors exist for the coagulant factors and proteases, is currently unresolved. The interaction between coagulation proteins and platelets is critical to the maintenance of normal hemostasis and is pathogenetically important in human disease.
引用
收藏
页码:48 / 59
页数:12
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