Unified perspective on proteins: A physics approach

被引：54

作者：

Banavar, JR ^{[1
]}

Hoang, TX

Maritan, A

Seno, F

Trovato, A

机构：

[1] Penn State Univ, Dept Phys, Davey Lab 104, University Pk, PA 16802 USA

[2] VAST, Inst Phys & Elect, Hanoi, Vietnam

[3] Univ Padua, INFM, I-35131 Padua, Italy

[4] Univ Padua, Dipartimento Fis G Galilei, I-35131 Padua, Italy

来源：

PHYSICAL REVIEW E | 2004年 / 70卷 / 04期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1103/PhysRevE.70.041905

中图分类号：

O35 [流体力学]; O53 [等离子体物理学];

学科分类号：

070204 ; 080103 ; 080704 ;

摘要：

We study a physical system which, while devoid of the complexity one usually associates with proteins, nevertheless displays a remarkable array of proteinlike properties. The constructive hypothesis that this striking resemblance is not accidental not only leads to a unified framework for understanding protein folding, amyloid formation, and protein interactions but also has implications for natural selection.

引用

页数：25

共 188 条

[141] DIFFERENTIAL GEOMETRY AND POLYMER CONFORMATION .3. SINGLE-SITE AND NEAREST-NEIGHBOR DISTRIBUTIONS, AND NUCLEATION OF PROTEIN FOLDING [J].

RACKOVSKY, S ;

SCHERAGA, HA .

MACROMOLECULES, 1981, 14 (05) :1259-1269

[142] DIFFERENTIAL GEOMETRY AND POLYMER CONFORMATION .4. CONFORMATIONAL AND NUCLEATION PROPERTIES OF INDIVIDUAL AMINO-ACIDS [J].

RACKOVSKY, S ;

SCHERAGA, HA .

MACROMOLECULES, 1982, 15 (05) :1340-1346

[143] Protein unfolding: Rigidity lost [J].

Rader, AJ ;

Hespenheide, BM ;

Kuhn, LA ;

Thorpe, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3540-3545

[144] INSIGHTS INTO PROTEIN-FOLDING USING PHYSICAL TECHNIQUES - STUDIES OF LYSOZYME AND ALPHA-LACTALBUMIN [J].

RADFORD, SE ;

DOBSON, CM .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1995, 348 (1323) :17-25

[145] From computer simulations to human disease: Emerging themes in protein folding [J].

Radford, SE ;

Dobson, CM .

CELL, 1999, 97 (03) :291-298

[146]

Ramachandran G N, 1968, Adv Protein Chem, V23, P283, DOI 10.1016/S0065-3233(08)60402-7

[147] THE DENOVO DESIGN OF PROTEIN STRUCTURES [J].

RICHARDSON, JS ;

RICHARDSON, DC .

TRENDS IN BIOCHEMICAL SCIENCES, 1989, 14 (07) :304-309

[148]

Riddle DS, 1999, NAT STRUCT BIOL, V6, P1016

[149] Functional rapidly folding proteins from simplified amino acid sequences [J].

Riddle, DS ;

Santiago, JV ;

BrayHall, ST ;

Doshi, N ;

Grantcharova, VP ;

Yi, Q ;

Baker, D .

NATURE STRUCTURAL BIOLOGY, 1997, 4 (10) :805-809

[150] HYDROPHOBICITY OF AMINO-ACID RESIDUES IN GLOBULAR-PROTEINS [J].

ROSE, GD ;

GESELOWITZ, AR ;

LESSER, GJ ;

LEE, RH ;

ZEHFUS, MH .

SCIENCE, 1985, 229 (4716) :834-838

← 10 11 12 13 14 15 16 17 18 19 →