Axon guidance to and from choice points

被引:50
作者
Cook, G [1 ]
Tannahill, D [1 ]
Keynes, R [1 ]
机构
[1] Univ Cambridge, Dept Anat, Cambridge CB2 3DY, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1016/S0959-4388(98)80009-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Significant progress has been made recently in understanding axon guidance to and from choice points. Netrins have been shown to function as conserved midline chemoattractants in vertebrates and insects, and receptors for netrins and semaphorins/collapsins have been identified. More evidence has accumulated that repulsion plays a key role in guidance, including the involvement of the ephrin/Eph receptor system in contact repulsion.
引用
收藏
页码:64 / 72
页数:9
相关论文
共 69 条
[1]   A novel class of murine semaphorins with homology to thrombospondin is differentially expressed during early embryogenesis [J].
Adams, RH ;
Betz, H ;
Puschel, AW .
MECHANISMS OF DEVELOPMENT, 1996, 57 (01) :33-45
[2]   PIONEER NEURONS IN AN INSECT EMBRYO [J].
BATE, CM .
NATURE, 1976, 260 (5546) :54-56
[3]   Semaphorin III Is needed for normal patterning and growth of nerves, bones and heart [J].
Behar, O ;
Golden, JA ;
Mashimo, H ;
Schoen, FJ ;
Fishman, MC .
NATURE, 1996, 383 (6600) :525-528
[4]   UNC-40, a C-elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues [J].
Chan, SSY ;
Zheng, H ;
Su, MW ;
Wilk, R ;
Killeen, MT ;
Hedgecock, EM ;
Culotti, JG .
CELL, 1996, 87 (02) :187-195
[5]   Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III [J].
Chen, H ;
Chedotal, A ;
He, ZG ;
Goodman, CS ;
TessierLavigne, M .
NEURON, 1997, 19 (03) :547-559
[6]   THE AXONAL CHEMOATTRACTANT NETRIN-1 IS ALSO A CHEMOREPELLENT FOR TROCHLEAR MOTOR AXONS [J].
COLAMARINO, SA ;
TESSIERLAVIGNE, M .
CELL, 1995, 81 (04) :621-629
[7]   AXON GUIDANCE MECHANISMS IN CAENORHABDITIS-ELEGANS [J].
CULOTTI, JG .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 1994, 4 (04) :587-595
[8]   ISOLATION FROM CHICK SOMITES OF A GLYCOPROTEIN FRACTION THAT CAUSES COLLAPSE OF DORSAL-ROOT GANGLION GROWTH CONES [J].
DAVIES, JA ;
COOK, GMW ;
STERN, CD ;
KEYNES, RJ .
NEURON, 1990, 4 (01) :11-20
[9]   Turning of retinal growth cones in a netrin-1 gradient mediated by the netrin receptor DCC [J].
de la Torre, JR ;
Höpker, VH ;
Ming, GL ;
Poo, MM ;
Tessier-Lavigne, M ;
Hemmati-Brivanlou, A ;
Holt, CE .
NEURON, 1997, 19 (06) :1211-1224
[10]   Netrin-1 and DCC mediate axon guidance locally at the optic disc: Loss of function leads to optic nerve hypoplasia [J].
Deiner, MS ;
Kennedy, TE ;
Fazeli, A ;
Serafini, T ;
TessierLavigne, M ;
Sretavan, DW .
NEURON, 1997, 19 (03) :575-589