Reaction between S-nitrosothiols and thiols:: Generation of nitroxyl (HNO) and subsequent chemistry

被引：325

作者：

Wong, PSY

Hyun, J

Fukuto, JM ^{[1
]}

Shirota, FN

DeMaster, EG

Shoeman, DW

Nagasawa, HT

机构：

[1] Univ Calif Los Angeles, Sch Med, Dept Pharmacol, Los Angeles, CA 90095 USA

[2] Univ Minnesota, Dept Med Chem, Minneapolis, MN 55455 USA

[3] Vet Affairs Med Ctr, Minneapolis, MN 55417 USA

来源：

BIOCHEMISTRY | 1998年 / 37卷 / 16期

关键词：

D O I：

10.1021/bi973153g

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-Nitrosothiols have been implicated to play key roles in a variety of physiological processes. The potential physiological importance of S-nitrosothiols prompted us to examine their reaction with thiols. We find that S-nitrosothiols can react with thiols to generate nitroxyl (HNO) and the corresponding disulfide. Further reaction of HNO with the remaining S-nitrosothiol and thiol results in the generation of other species including NO, sulfinamide, and hydroxylamine. Mechanisms are proposed that rationalize the observed products.

引用

页码：5362 / 5371

页数：10

共 52 条

[1]

AMELLE DR, 1995, ARCH BIOCHEM BIOPHYS, V318, P279

[2] CHEMICAL MECHANISMS UNDERLYING THE VASODILATOR AND PLATELET ANTI-AGGREGATING PROPERTIES OF S-NITROSO-N-ACETYL-DL-PENICILLAMINE AND S-NITROSOGLUTATHIONE [J].