What's new in the IGF-binding proteins?

被引：58

作者：

Rosenzweig, SA ^{[1
]}

机构：

[1] Med Univ S Carolina, Hollings Canc Ctr, Dept Cell & Mol Pharmacol & Expt Therapeut, Charleston, SC 29403 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2004年 / 14卷 / 05期

关键词：

insulin-like growth factor (IGF); IGF binding protein (IGFBP); 1GF-1 receptor (IGF-IR); binding sited structure-function;

D O I：

10.1016/j.ghir.2004.02.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Since their initial discovery over 25 years ago as IGF carrier proteins, the insulin-like growth factor binding protein (IGFBP) family has grown to six members, ranging in size from 216 to 289 amino acids. The assumption over the years has been that this family of proteins, having higher affinities for IGF-I and IGF-II than does the IGF-IR, serves to block access of these ligands to the receptor. Although the need for such regulatory proteins is consistent with the constitutive secretion of IGFs from many cell types, it is not surprising that additional functions have begun to be uncovered for these proteins. This review will examine new and old actions of the IGFBPs from a biochemical and cell biological perspective. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：329 / 336

页数：8

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