Safety, tolerability and preliminary evidence for antidepressant efficacy of theta-burst transcranial magnetic stimulation in patients with major depression

被引：93

作者：

Chistyakov, Andrei V. ^{[2
]}

Rubicsek, Odil ^{[1
]}

Kaplan, Boris ^{[2
]}

Zaaroor, Menashe ^{[2
]}

Klein, Ehud ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Rambam Med Ctr, Dept Psychiat, B Rappaport Fac Med, IL-31096 Haifa, Israel

[2] Technion Israel Inst Technol, Rambam Med Ctr, Dept Neurosurg, B Rappaport Fac Med, IL-31096 Haifa, Israel

来源：

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2010年 / 13卷 / 03期

关键词：

Major depression; safety; theta-burst transcranial magnetic stimulation; tolerability; therapeutic efficacy; HUMAN MOTOR CORTEX; SOMATOSENSORY-EVOKED POTENTIALS; PREFRONTAL CORTEX; CORTICAL EXCITABILITY; RESISTANT DEPRESSION; CONTROLLED-TRIAL; MOOD; PLASTICITY; FREQUENCY;

D O I：

10.1017/S1461145710000027

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The aim of this open study was to evaluate the safety and tolerability of theta-burst transcranial magnetic stimulation (TBS) and to assess preliminarily its therapeutic efficacy in patients with major depression. A total of 33 patients were assigned to receive one of four TBS protocols for 10 consecutive work days. TBS consisted of triple-pulse 50-Hz bursts given at a rate of 5 Hz to the left or right dorsolateral prefrontal cortex at different stimulation parameters. Severity of depression was assessed by the Hamilton Depression Rating Scale. Our results indicate that TBS as applied in this study is safe and well tolerated in depressed patients and seems to have antidepressant properties. Increase of stimulation parameters is not associated with more side-effects and adds to its therapeutic effect.

引用

页码：387 / 393

页数：7

共 23 条

[1] Opinion -: Is mood chemistry? [J].

Castrén, E .

NATURE REVIEWS NEUROSCIENCE, 2005, 6 (03) :241-246

[2] Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].

Chen, R ;

Classen, J ;

Gerloff, C ;

Celnik, P ;

Wassermann, EM ;

Hallett, M ;

Cohen, LG .

NEUROLOGY, 1997, 48 (05) :1398-1403

[3] Antidepressant effects of different schedules of repetitive transcranial magnetic stimulation vs. clomipramine in patients with major depression: relationship to changes in cortical excitability [J].

Chistyakov, AV ;

Kaplan, B ;

Rubichek, O ;

Kreinin, I ;

Koren, D ;

Feinsod, M ;

Klein, E .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2005, 8 (02) :223-233

[4] Effect of electroconvulsive therapy on cortical excitability in patients with major depression: a transcranial magnetic stimulation study [J].

Chistyakov, AV ;

Kaplan, B ;

Rubichek, O ;

Kreinin, I ;

Koren, D ;

Hafner, H ;

Feinsod, M ;

Klein, E .

CLINICAL NEUROPHYSIOLOGY, 2005, 116 (02) :386-392

[5]

Feinsod M, 1998, Depress Anxiety, V7, P65

[6] A randomized, controlled trial of sequential bilateral repetitive transcranial magnetic stimulation for treatment-resistant depression [J].

Fitzgerald, PB ;

Benitez, J ;

de Castella, A ;

Daskalakis, ZJ ;

Brown, TL ;

Kulkarni, J .

AMERICAN JOURNAL OF PSYCHIATRY, 2006, 163 (01) :88-94

[7] Improvement of depression following transcranial magnetic stimulation. [J].

George M.S. ;

Nahas Z. ;

Kozel F.A. ;

Goldman J. ;

Molloy M. ;

Oliver N. .

Current Psychiatry Reports, 1999, 1 (2) :114-124

[8] Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial [J].

George, MS ;

Wassermann, EM ;

Kimbrell, TA ;

Little, JT ;

Williams, WE ;

Danielson, AL ;

Greenberg, BD ;

Hallett, M ;

Post, RM .

AMERICAN JOURNAL OF PSYCHIATRY, 1997, 154 (12) :1752-1756

[9] A controlled trial of daily left prefrontal cortex TMS for treating depression [J].

George, MS ;

Nahas, Z ;

Molloy, M ;

Speer, AM ;

Oliver, NC ;

Li, XB ;

Arana, GW ;

Risch, SC ;

Ballenger, JC .

BIOLOGICAL PSYCHIATRY, 2000, 48 (10) :962-970

[10] Theta Burst Stimulation of the Prefrontal Cortex: Safety and Impact on Cognition, Mood, and Resting Electroencephalogram [J].

Grossheinrich, Nicola ;

Rau, Anne ;

Pogarell, Oliver ;

Hennig-Fast, Kristina ;

Reinl, Maren ;

Karch, Susanne ;

Dieler, Alica ;

Leicht, Gregor ;

Mulert, Christoph ;

Sterr, Andrea ;

Padberg, Frank .

BIOLOGICAL PSYCHIATRY, 2009, 65 (09) :778-784

← 1 2 3 →