学术探索
学术期刊
新闻热点
数据分析
智能评审

Signaling pathways in Th2 development

被引：187
作者：
Mowen, KA [1 ]
Glimcher, LH [1 ]
机构：
[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA
来源：
IMMUNOLOGICAL REVIEWS | 2004年 / 202卷
关键词：
D O I：
10.1111/j.0105-2896.2004.00209.x
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In order for an immune response to be successful, it must be of the appropriate type and magnitude. Intracellular residing pathogens require a cell-mediated immune response, whereas extracellular pathogens evoke a humoral immune response. T-helper (Th) cells orchestrate the immune response and are divided into two subsets, Th1 and Th2 cells. Here, we discuss the mechanisms of Th2 development with a focus on signal transduction pathways that influence Th2 differentiation.
引用
收藏
页码：203 / 222
页数：20
相关论文
共 283 条
  • [1] Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
    Agarwal, S
    Avni, O
    Rao, A
    [J]. IMMUNITY, 2000, 12 (06) : 643 - 652
  • [2] Induction of T helper type 2 immunity by a point mutation in the LAT adaptor
    Aguado, E
    Richelme, S
    Nuñez-Cruz, S
    Miazek, A
    Mura, AM
    Richelme, M
    Guo, XJ
    Sainty, D
    He, HT
    Malissen, B
    Malissen, M
    [J]. SCIENCE, 2002, 296 (5575) : 2036 - 2040
  • [3] Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745
  • [4] Suppressors of cytokine signalling (SOCS) in the immune system
    Alexander, WS
    [J]. NATURE REVIEWS IMMUNOLOGY, 2002, 2 (06) : 410 - 416
  • [5] The role of suppressors of cytokine signaling (SOCS) proteins in regulation of the immuneresponse
    Alexander, WS
    Hilton, DJ
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 : 503 - 529
  • [6] Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation
    Andres, PG
    Howland, KC
    Nirula, A
    Kane, LP
    Barron, L
    Dresnek, D
    Sadra, A
    Imboden, J
    Weiss, A
    Abbas, AK
    [J]. NATURE IMMUNOLOGY, 2004, 5 (04) : 435 - 442
  • [7] An epigenetic view of helper T cell differentiation
    Ansel, KM
    Lee, DU
    Rao, A
    [J]. NATURE IMMUNOLOGY, 2003, 4 (07) : 616 - 623
  • [8] Aronica MA, 1999, J IMMUNOL, V163, P5116
  • [9] Aune TM, 1999, J IMMUNOL, V162, P5805
  • [10] TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    Avni, O
    Lee, D
    Macian, F
    Szabo, SJ
    Glimcher, LH
    Rao, A
    [J]. NATURE IMMUNOLOGY, 2002, 3 (07) : 643 - 651
12345678910